Fedele was born in Lecce, Italy, in 1953. After studying at the Conservatory in Milan and the Accademia Santa Cecilia in Rome (though he also studied philosophy at the Università degli Studi di Milano), at the early age of 28 he won the Gaudeamus Award (for the first String Quartet and Chiari for orchestra), which launched him on the international scene. In 1989, his composition for orchestra Epos won the Petrassi Competition in Parma. Antigone, an opera commissioned by the Teatro Comunale in Florence for the opening night of the Maggio Musicale, was awarded the Premio Abbiati by the Association of Italian Music Critics as the best new work of 2007. The Cd Animus Anima received the Choc de la Musique 2003 from the magazine “Le Monde de la Musique”, whereas Maya was awarded the Coup de Coeur 2004 by the Académie Charles Cros and Mixtim won the Premio del Disco Amadeus in the contemporary category for the year 2007. In addition to his many chamber works, he has also composed pieces for orchestra alone, concertos or symphonic-vocal music, of which the most recent include En archè and 33 noms (a commission from the Teatro La Scala in Milan).
His music has been conducted, among others, by Boulez, Eschenbach, Chung, Saalonen, Muti, Slatkin, Robertson, Kalitze, Wit, Valade and Rophè and performed by orchestras and ensembles such as the BBC, Berlin Radio, Chicago Symphony Orchestra, Stuttgart SWR, National de France, National de Lyon, Warsaw Symphony Orchestra, Orchestra Sinfonica Nazionale della RAI, Santa Cecilia, Ensemble Intercontemporain, London Sinfonietta, Klangforum Wien, etc.
In 2001 he was honoured by the French Ministry of Culture with the title of Chevalier de l’Ordre des Lettres et des Arts. In 2005 he was appointed a Member of the Accademia Nazionale di Santa Cecilia in Rome. In 2007 the Italian Minister of Culture assigned him the Chair in Composition for the Master Courses in Music Studies at the Accademia.